Histopathological characteristics of renal changes in humanrenin-angiotensinogen double transgenic rats

Histopathological characteristics of renal changes in human renin-angiotensinogen double transgenic rats

The human renin-angiotensinogen double transgenic rat (dTGR) is a model of hypertension. The aim of this short report was to describe the histopathological characteristics of the renal changes in this rat strain in detail. Seven to nine-week-old male dTGRs were euthanized, and their kidneys were histopathologically examined. At the time of sacrifice, the average systolic blood pressure of the d...

Crataegus monogyna extract on renal histopathological changes in diabetic rats

Renal complications is considered as important cause of mortality in diabetic patients. This study investigated the effect of hydroalcoholic extract of C. monogyna on renal histopathological changes in diabetic rats. In this experimental study 40 male Wistar rats were divided into 5 groups (n=8) including control (receiving normal saline), diabetic (receiving streptozotocin), treatment groups ...

Decreased susceptibility of cardiac contractile function to hypoxia- reoxygenation in renin-angiotensinogen double-transgenic rats

Effects of human prorenin in rats transgenic for human angiotensinogen.

The physiological role of prorenin is unknown; however, the possibility that prorenin inhibits renin locally has been suggested. We tested the hypothesis that prorenin may be an endogenous competitor for renin uptake in the tissue. We also investigated whether prorenin can be activated to active renin and affect mean arterial pressure (MAP). Isolated perfused hindquarters of rats transgenic for...

Renal histopathological and biochemical changes following adjuvant intervention of Momordica charantia and antiretroviral therapy in diabetic rats

Objective(s): Diabetic nephropathy (DN) is an important primary cause of end-stage kidney disease. This study explores the mechanisms of the reno-protective effects of Momordica charantia (M. charantia) in diabetic rats following treatment with highly active antiretroviral therapy (HAART) regimen triplavar. Materials and Methods: Adult m...